UNIV-Post Doctoral Scholar-Department of Biochemistry

Job Description Summary

Dr. Delaney, PhD, has an opening in his laboratory for a self-motivated and independent Postdoctoral Scholar. Delaney Lab projects are centered on investigating how chromosomal copy number changes alter cell biology, particularly in the context of cancer using mice and cancer cell lines as model systems. This position requires a post-doctoral fellow to investigate metallothioneins: zinc binding proteins of relatively unknown contribution to cancer initiation and drug response. The scientific culture in the lab is to initially design projects from unbiased genome-wide assays (bioinformatic or –seq technologies) from the highest quality genetic models and work out full mechanistic stories from the outcome.The ideal candidate has previous experience in a cancer biology laboratory, however this is not required if the candidate has demonstrated productivity as evidenced by peer-reviewed publications. Opportunities to learn and use R for bioinformatic data science are also available and encouraged. Dr. Delaney leads the Biological Big Data for Basic Scientists course at MUSC. The ideal candidate is well-organized and able to create documentation in Word, Excel, and Google Docs. The Postdoctoral Scholar must be able to work well in a team setting, including the mentoring of undergraduates and colleagues. Previous experience with mice, microscopy, metabolic assays, cell culture, and bacterial plasmid preps is desired but not required. Previous experience with Cas9-directed mutagenesis beyond simple knockouts is desired but not required. The candidate must be willing to work with mice and lentivirus in an oncology context. The candidate is expected to work hard while in the laboratory, however Dr. Delaney’s lab culture fosters work-life balance.

Entity

Medical University of South Carolina (MUSC - Univ)

Worker Type

Employee

Worker Sub-Type​

Regular

Cost Center

CC000954 COM BIOCHEM Operations CC

Pay Rate Type

Salary

Pay Grade

University-00

Pay Range

$0 - $0 - $0

Scheduled Weekly Hours

40

Work Shift

Job Description

Job Description:

Dr. Delaney, PhD, has an opening in his laboratory for a self-motivated and independent Postdoctoral Scholar.

Delaney Lab projects are centered on investigating how chromosomal copy number changes alter cell biology, particularly in the context of cancer using mice and cancer cell lines as model systems. This position requires a post-doctoral fellow to investigate metallothioneins: zinc binding proteins of relatively unknown contribution to cancer initiation and drug response. The scientific culture in the lab is to initially design projects from unbiased genome-wide assays (bioinformatic or –seq technologies) from the highest quality genetic models and work out full mechanistic stories from the outcome. The ideal candidate has previous experience in a cancer biology laboratory; however, this is not required if the candidate has demonstrated productivity as evidenced by peer-reviewed publications. Opportunities to learn and use R for bioinformatic data science are also available and encouraged. Dr. Delaney leads the Biological Big Data for Basic Scientists course at MUSC. The ideal candidate is well-organized and able to create documentation in Word, Excel, and Google Docs. The Postdoctoral Scholar must be able to work well in a team setting, including the mentoring of undergraduates and colleagues. Previous experience with mice, microscopy, metabolic assays, cell culture, and bacterial plasmid preps is desired but not required. Previous experience with Cas9-directed mutagenesis beyond simple knockouts is desired but not required. The candidate must be willing to work with mice and lentivirus in an oncology context. The candidate is expected to work hard while in the laboratory, however Dr. Delaney’s lab culture fosters work-life balance.

Job Duties:

Molecular biology assays, westerns, RT-qPCR, DNA isolation, microscopy (Essential - 20%)

Maintain mouse colony specific to project including genotyping and monitoring (Essential - 15%)

Perform mouse experiments, including tumor cell inoculation, chemotherapeutic treatment, dissections, histology, and related molecular biology (Essential - 15%)

Genetic manipulation of mouse and human genes using cutting-edge molecular biology techniques, DNA and RNA purification (Essential - 10%).

Prepare cell culture samples by transfection and/or lentivirus (Essential - 10%)

Participation in shared lab duties, i.e. reagent maintenance and inventory, general equipment/lab maintenance, data management (Essential - 10%).

Write and submit highly competitive applications for fellowships and grants relevant to the trainee (Essential - 10%)

Scholarly activities- including manuscript preparation, poster and oral presentations at conferences. (Essential-5%).

Keep the lab organized and clean (Essential - 5%).

Additional Job Description

Physical Requirements: (Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Continuous) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb stairs. (Infrequent) Ability to work indoors. (Continuous) Ability to work in all cold temperature extremes, i.e. spot coolers. (Frequent) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to perform 'pinching' operations. (Continuous) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Continuous) Ability to fully use both legs. (Continuous) Ability to reach in all directions. (Continuous) Possess good finger dexterity. (Continuous) Ability to maintain tactile sensory functions. (Continuous) Ability to maintain good olfactory sensory function. (Continuous) Ability to lift and carry 15 lbs., unassisted. (Frequent) Ability to lift objects, up to 15 lbs., from floor level to height of 72 inches, unassisted. (Frequent) Ability to lower objects, up to 15 lbs., from height of 72 inches to floor level, unassisted. (Frequent) Ability to push/pull objects, up to 15 lbs., unassisted. (Infrequent) Ability to lift and carry objects up to 15 lbs. a distance of five (5) floors and to outlying buildings. (Frequent) Ability to maintain 20/40 vision, corrected. (Continuous) Ability to see and recognize objects close at hand. (Continuous) Ability to see and recognize objects at a distance. (Continuous) Ability to match or discriminate between colors. (Continuous) Ability to determine distance/relationship between objects; depth perception. (Continuous) Good peripheral vision capabilities. (Continuous) Ability to maintain hearing acuity, with correction. (Continuous) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to be qualified physically (by medical personnel) for respirator use, initially and annually. Ability to work alone in isolated areas, such as darkrooms. (Frequent) Additional New Requirements: Ability to obtain and maintain a valid drivers license. Computer literacy. Ability to work rotating shifts as required. Ability to work overtime as required. Ability to learn and use new processes, tools and equipment as required.

If you like working with energetic enthusiastic individuals, you will enjoy your career with us!

The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.

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