UNIV - Postdoctoral Scholar - Biochemistry and Molecular Biology

  • 548286
  • Charleston, South Carolina
  • COLLEGE OF MEDICINE - COM-Biochemistry & Molecular
  • Clinical & Research Support Services
  • Full Time

FLSA: Salaried

 

Payscale Salary Range: UNIV-Band 0: Commensurate with experience.

 

Job Summary: Dr. Delaney, PhD, has an opening in his laboratory for a self-motivated and independent Postdoctoral Scholar.
Delaney Lab projects are centered on investigating how chromosomal copy number changes alter cell biology, particularly in the context of cancer using mice and cancer cell lines as model systems. This position requires a post-doctoral fellow to investigate metallothioneins: zinc binding proteins of relatively unknown contribution to cancer initiation and drug response. The scientific culture in the lab is to initially design projects from unbiased genome-wide assays (bioinformatic or –seq technologies) from the highest quality genetic models and work out full mechanistic stories from the outcome.

 

Job Duties: 

  • 20% - Molecular biology assays, westerns, RT-qPCR, DNA isolation, microscopy. - (Essential)
  • 15% - Perform mouse experiments, including tumor cell inoculation, chemotherapeutic treatment, dissections, histology, and related molecular biology. - (Essential)
  • 15% - Maintain mouse colony specific to project including genotyping and monitoring. - (Essential)
  • 10% - Genetic manipulation of mouse and human genes using cutting-edge molecular biology techniques, DNA and RNA purification. - (Essential)
  • 10% - Prepare cell culture samples by transfection and/or lentivirus. - (Essential)
  • 10% - Participation in shared lab duties, i.e. reagent maintenance and inventory, general equipment/lab maintenance, data management. - (Essential)
  • 10% - Write and submit highly competitive applications for fellowships and grants relevant to the trainee. - (Essential)
  • 5% - Scholarly activities- including manuscript preparation, poster and oral presentations at conferences. - (Essential)
  • 5% - Keep the lab organized and clean. - (Essential)

 

Preferred Experience & Additional Skills: The ideal candidate has previous experience in a cancer biology laboratory, however this is not required if the candidate has demonstrated productivity as evidenced by peer-reviewed publications.

Opportunities to learn and use R for bioinformatic data science are also available and encouraged. Dr. Delaney leads the Biological Big Data for Basic Scientists course at MUSC.  The ideal candidate is well-organized and able to create documentation in Word, Excel, and Google Docs. The Postdoctoral Scholar must be able to work well in a team setting, including the mentoring of undergraduates and colleagues. Previous experience with mice, microscopy, metabolic assays, cell culture, and bacterial plasmid preps is desired but not required. Previous experience with Cas9-directed mutagenesis beyond simple knockouts is desired but not required.
The candidate must be willing to work with mice and lentivirus in an oncology context.  The candidate is expected to work hard while in the laboratory, however Dr. Delaney’s lab culture fosters work-life balance.

Physical Requirements: Ability to perform job functions in an upright position. (Frequent) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb, using step stool. (Infrequent) Ability to work in temperature extremes (32? F to 100? F) when required due to assignments in cold rooms and/or foreign countries. (Infrequent) Ability to work in confined/cramped spaces. (Continuous) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Frequent) Ability to fully use both legs. (Frequent) Ability to reach in all directions, stretch, bend, while moving items/materials from both sitting and standing positions. (Frequent) Ability to maintain good olfactory sensory function/distinction. (Continuous) Ability to lift materials up to 20 lbs., unassisted. (Infrequent) Ability to lift and carry 4 liter waste material bottles a distance of 30 feet, unassisted. (Frequent) Ability to lift and carry 25-30 lbs. jugs of liquid a distance of 100 feet, unassisted. (Infrequent) Ability to lift file boxes, from floor level to counter tops, unassisted. (Frequent) Ability to push/ Ability to lift 40 lbs. centrifuge rotors from floor level to height of 40 inches, then down 20 inches into centrifuge drum, unassisted. (Infrequent) Ability to lift 25 lbs. boxes, from floor level to maximum height of 72 inches, unassisted. (Infrequent) Ability to push/pull file boxes from one location to another at floor level. (Frequent) Ability to maneuver heavy equipment on bench tops, 50 lbs. or greater, unassisted. (Frequent) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to maintain 20/20 vision, corrected. (Continuous) Ability to match or discriminate between colors, normally. (Continuous) Ability to hear and recognize various alarms emitting from work area systems. (Continuous) Ability to hear and/or understand conversations. (Continuous) Ability to work in a darkroom for processing film, etc. (Continuous) Ability to be qualified physically for respirator use, initially and annually. (Continuous)

 

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