UNIV - Research Specialist II - Department of Medicine - Division of Hematology Oncology

Job Description Summary

The Wrangle Lab at the Medical University of South Carolina is seeking applicants for a Research Specialist II position. Responsibilities of this position will include performing experiments involving laboratory mice, molecular biology and biochemical assays, and data analysis. Prior experience with in vivo and in vitro work is preferred. Research interests of the Wrangle Lab focus on the development of novel therapeutic strategies and biomarkers for the treatment and diagnosis of non-small cell lung cancer (NSCLC). Dr. Wrangle’s research team hypothesizes that NSCLC may be classified by immune-phenotypes based on expression patterns of immune-related genes and pathways known to be important mechanisms of immune escape. This research is facilitated by clinical trials and in close collaboration with several MUSC oncologists and surgeons.

Entity

Medical University of South Carolina (MUSC - Univ)

Worker Type

Employee

Worker Sub-Type​

Research Grant

Cost Center

CC001335 HCC Research & Pilots

Pay Rate Type

Hourly

Pay Grade

University-05

Pay Range

38,985.00 - 55,559.50 - 72,134.000

Scheduled Weekly Hours

40

Work Shift

Job Description

Job Duties:

35% - Small laboratory animals

• Administration of drugs and cells (i.v., i.p., s.c. injections)

• Collection and processing of fluids and tissues for downstream analysis

• Monitoring of tumor growth with in vivo imaging and calipers

• Oversee overlapping experiments and sacrifice mice at set time points

35% - Experiments investigating cellular and molecular mechanisms involved in immune cell function

• Receiving and processing biologic samples from the clinic

• Performing immunological/genetic analyses on samples from clinical trial patients

• Cell culture

• Utilizing cell and molecular biology techniques including flow cytometry, molecular cloning and enzymatic assays, transfections and gene expression assays, protein, RNA and DNA isolation and separation, ELISA, PCR, Western blotting, proliferation and apoptosis assays, electroporation, and immunohistochemistry, confocal microscopy, immunofluorescence staining

• Developing and optimizing protocols for in vitro and in vivo experiments

20% - Data analysis and presentation

• Graphing and visualization of data with software including Graphpad Prism, FlowJo, Snapgene, Biorender, and Adobe Illustrator

• Presenting data during lab meetings, as well as analyzing and preparing data for external collaborators

• Preparing publication quality figures, may be involved in writing of manuscripts

• Efforts will directly contribute to grant applications and manuscripts

10% -  General laboratory responsibilities

• Maintenance of laboratory instruments, supplies, and equipment

• Maintenance of laboratory notebooks and records related to protocols, policy and regulation

• Assist with ordering reagents and supplies

Preferred Experience & Additional Skills: one year work experience, or 10 years of experience in mouse handling, cell culture, molecular biology, and skills listed under Job Duties.

Additional Job Description

Minimum Requirements: A bachelor's degree in chemistry, biology, or other natural, life or health care science and one year work experience directly related to the assigned research area.

Physical Requirements: (Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Frequent) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb, using step stool. (Infrequent) Ability to work in temperature extremes (32° F to 100° F) when required due to assignments in cold rooms and/or foreign countries. (Infrequent) Ability to work in confined/cramped spaces. (Continuous) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Frequent) Ability to fully use both legs. (Frequent) Ability to reach in all directions, stretch, bend, while moving items/materials from both sitting and standing positions. (Frequent) Ability to maintain good olfactory sensory function/distinction. (Continuous) Ability to lift materials up to 20 lbs., unassisted. (Infrequent) Ability to lift and carry 4 liter waste material bottles a distance of 30 feet, unassisted. (Frequent) Ability to lift and carry 25-30 lbs. jugs of liquid a distance of 100 feet, unassisted. (Infrequent) Ability to lift file boxes, from floor level to counter tops, unassisted. (Frequent) Ability to push/ Ability to lift 40 lbs. centrifuge rotors from floor level to height of 40 inches, then down 20 inches into centrifuge drum, unassisted. (Infrequent) Ability to lift 25 lbs. boxes, from floor level to maximum height of 72 inches, unassisted. (Infrequent) Ability to push/pull file boxes from one location to another at floor level. (Frequent) Ability to maneuver heavy equipment on bench tops, 50 lbs. or greater, unassisted. (Frequent) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to maintain 20/40 vision, corrected, in one eye or with both eyes. (Continuous) Ability to match or discriminate between colors, normally. (Continuous) Ability to hear and recognize various alarms emitting from work area systems. (Continuous) Ability to hear and/or understand conversations. (Continuous) Ability to work in a darkroom for processing film, etc. (Continuous) Ability to be qualified physically for respirator use, initially and annually. (Continuous)

Additional New Requirements: Ability to work rotating shifts as required. Ability to work overtime as required. Ability to learn and use new processes, tools and equipment as required.

If you like working with energetic enthusiastic individuals, you will enjoy your career with us!

The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.

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