UNIV - Post Doctoral Scholar- Pharmacology and Immunology

Job Description Summary

The cell death/cellular bucket list pathways should be beneficial during infection but could be mutated and become detrimental in cancer.

The Nozaki lab, started at MUSC from Sep 1st , 2024, aims to uncover fundamental understanding of intestinal immunity during infection and inflammation, especially by focusing on cell death and its-associated pathways. The lab also aims to elucidate how intestinal inflammation affects the tumor evolution and its microenvironment, and how those mechanisms can be applied to therapeutics.
To achieve this goal, my lab will develop novel mouse models as well as novel organoid models which can analyze the complicated death signaling and cell-to-cell, host-pathogen interactions.

Under the direct supervision of the Principal Investigator, a postdoctoral associate is needed to perform immunology research for the analysis of mouse/human gut tissues and cells. Responsible for mouse maintenance, sample preparation and analysis for PCR/qPCRs, Western Blots, flow cytometry, immunofluorescence, maintaining instrumentation and laboratory resources. Having experience of those techniques is a plus, but not necessarily required. The lab can provide various training opportunities.

Entity

Medical University of South Carolina (MUSC - Univ)

Worker Type

Employee

Worker Sub-Type​

Regular

Cost Center

CC001032 COM PHARM Administration CC

Pay Rate Type

Salary

Pay Grade

University-00

Pay Range

0.00 - 0.00 - 0.000

Scheduled Weekly Hours

40

Work Shift

Job Description

30%- Collaborates with the PI and other lab members involved to design and execute experiments using state-of-the-art immunology/cell biology techniques and epithelial organoid culture technologies to study the cell death, infection, inflammation, and colorectal cancer progression in genetic mouse models and patient derived samples. These duties include mouse breeding, genotyping, mouse infection / dissection / tissue harvesting, histopathology analysis, organoid culture, organoid engineering, molecular cloning, quantitative real time PCR, Western blot, immunostaining, microscopy, and flow cytometry.

30%- Collaborates in collecting and analyzing data generated from the experiments and duties include keeping accurate records on a daily basis, identifying and using appropriate software for analysis of data, discussing the data and planning new experiments with PI.

30%- Collaborates in preparing manuscripts and grants based on the experimental data generated. Duties include keeping current with the literature, preparing figures based on data collected, writing manuscripts and sections of grants with the PI and senior team members, attending and presenting in relevant seminars and conferences inside and outside the university.

10%- Helps with laboratory maintenance and regulatory compliance, such as  ordering, cleanup of lab areas, maintenance of equipment, helping to prepare IACUC protocols and amendments when appropriate.

Minimum MUSC Requirements: PhD

Additional Requirements and Training: PhD in Immunology, cell biology, or related field. Related techniques : genetic mouse modeling, mammalian cell and tissue culture, microscopy, flow cytometry, and standard techniques analyzing DNA, RNA, and protein. Organoid experience is a plus, but not necessarily required. The lab has expertise and will provide great training opportunities.

Additional Job Description

Physical Requirements: (Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Continuous) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb stairs. (Infrequent) Ability to work indoors. (Continuous) Ability to work in all cold temperature extremes, i.e. spot coolers. (Frequent) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to perform 'pinching' operations. (Continuous) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Continuous) Ability to fully use both legs. (Continuous) Ability to reach in all directions. (Continuous) Possess good finger dexterity. (Continuous) Ability to maintain tactile sensory functions. (Continuous) Ability to maintain good olfactory sensory function. (Continuous) Ability to lift and carry 15 lbs., unassisted. (Frequent) Ability to lift objects, up to 15 lbs., from floor level to height of 72 inches, unassisted. (Frequent) Ability to lower objects, up to 15 lbs., from height of 72 inches to floor level, unassisted. (Frequent) Ability to push/pull objects, up to 15 lbs., unassisted. (Infrequent) Ability to lift and carry objects up to 15 lbs. a distance of five (5) floors and to outlying buildings. (Frequent) Ability to maintain 20/40 vision, corrected. (Continuous) Ability to see and recognize objects close at hand. (Continuous) Ability to see and recognize objects at a distance. (Continuous) Ability to match or discriminate between colors. (Continuous) Ability to determine distance/relationship between objects; depth perception. (Continuous) Good peripheral vision capabilities. (Continuous) Ability to maintain hearing acuity, with correction. (Continuous) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to be qualified physically (by medical personnel) for respirator use, initially and annually. Ability to work alone in isolated areas, such as darkrooms. (Frequent) Additional New Requirements: Ability to obtain and maintain a valid drivers license. Computer literacy. Ability to work rotating shifts as required. Ability to work overtime as required. Ability to learn and use new processes, tools and equipment as required.

If you like working with energetic enthusiastic individuals, you will enjoy your career with us!

The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.

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