UNIV-Staff Scientist II-Department of Biochemistry

Job Description Summary

Seeking a highly motivated individual to fill a Senior Staff Scientist position in a cancer research laboratory in the Department of Biochemistry and Molecular Biology at the Medical University of South Carolina. Current work in the laboratory is centered on cellular signaling related to hypoxia and drug resistance in prostate cancer. Research in the laboratory is focused on two major areas: 1. The role if PIM kinases in tumor metastasis; and 2. Discovery of novel hypoxia targeting agents.

Applicants must have a Ph.D. with considerable experience in molecular biology, biochemistry, cell biology, and experience in utilizing in vivo models of prostate cancer and surgical techniques. The selected candidate should have a strong track record in publishing high impact research, as well as a history of training and oversight of graduate students, postdoctoral fellows and other research staff. The candidate will be expected to lead independent research projects and assist with the development of research proposals for external research funding from both federal and private agencies. The candidate will also be expected to present his/her work at lab meetings, departmental retreats, national/international scientific conferences and publish his/her findings in collaboration with the PI in high impact scientific journals.

Applicants must be eligible for employment in the U.S. This is a non tenure-track position, with renewal dependent on continued availability of extramural funding. Salary range is commensurate with experience.

Entity

Medical University of South Carolina (MUSC - Univ)

Worker Type

Employee

Worker Sub-Type​

Research Grant

Cost Center

CC000954 COM BIOCHEM Operations CC

Pay Rate Type

Salary

Pay Grade

University-00

Pay Range

0.00 - 0.00 - 0.000

Scheduled Weekly Hours

40

Work Shift

Job Description

Job Description:

Seeking a highly motivated individual to fill a Senior Staff Scientist position in a cancer research laboratory in the Department of Biochemistry and Molecular Biology at the Medical University of South Carolina. Current work in the laboratory is centered on cellular signaling related to hypoxia and drug resistance in prostate cancer. Research in the laboratory is focused on two major areas: 1. The role if PIM kinases in tumor metastasis; and 2. Discovery of novel hypoxia targeting agents.

Applicants must have a Ph.D. with considerable experience in molecular biology, biochemistry, cell biology, and experience in utilizing in vivo models of prostate cancer and surgical techniques.  The selected candidate should have a strong track record in publishing high impact research, as well as a history of training and oversight of graduate students, postdoctoral fellows and other research staff. The candidate will be expected to lead independent research projects and assist with the development of research proposals for external research funding from both federal and private agencies. The candidate will also be expected to present his/her work at lab meetings, departmental retreats, national/international scientific conferences and publish his/her findings in collaboration with the PI in high impact scientific journals.

Applicants must be eligible for employment in the U.S. This is a non-tenure-track position, with renewal dependent on continued availability of extramural funding. Salary range is commensurate with experience.

Minimum Requirements:

Ph.D. or equivalent with 5 years post doctorate experience plus evidence of scholarly activity as demonstrated by at least 5 first-author publications.

Job Duties:

Develop an independent research project in consultation with the PI (30%).  The individual will be responsible for the design and implementation of experiments in the area of signaling transduction and cancer

biology. This will include a review of current scientific literature, maintain meticulous laboratory records, and presenting these results to PI in individual and group meetings. The individual will be responsible for drafting and publication of results in leading scientific journals, and will work closely with PI to develop research grant proposals.

 

Perform in vivo experiments to assess drug efficacy and differential biology in prostate cancer (30%). The individual will be lead in vitro  and in vivo testing of novel inhibitors identified and developed by the lab and its collaborators.  This includes orthotopic models of prostate cancer and bone orthotopic models of metastasis.  The individual will have experience performing pK studies, urological surgeries in mice and all modalities of drug delivery, including intraperitoneal, oral gavage, retro-orbital, and tail vein injections, among others, as well as necropsy and tissue collection from primary and distant organs.

 

Training and supervision of technical staff, graduate students, and other laboratory personnel (30%). The individual should have experience mentoring students. This includes oversight of equipment, developing written protocols of experimental techniques, advising and assisting junior members of the laboratory on experimental approaches.

 

Lab management (10%). The individual will have experience with oversight of daily lab needs, activity and budgeting. This includes, but is not limited to, maintaining databases of laboratory reagents, cell lines, and ordering supplies.

Additional Job Description

Physical Requirements: (Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Continuous) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb stairs. (Infrequent) Ability to work indoors. (Continuous) Ability to work in all cold temperature extremes, i.e. spot coolers. (Frequent) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to perform 'pinching' operations. (Continuous) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Continuous) Ability to fully use both legs. (Continuous) Ability to reach in all directions. (Continuous) Possess good finger dexterity. (Continuous) Ability to maintain tactile sensory functions. (Continuous) Ability to maintain good olfactory sensory function. (Continuous) Ability to lift and carry 30 lbs., unassisted. (Frequent) Ability to lift objects, up to 30 lbs., from floor level to height of 72 inches, unassisted. (Frequent) Ability to lower objects, up to 30 lbs., from height of 72 inches to floor level, unassisted. (Frequent) Ability to push/pull objects, up to 50 lbs., unassisted. (Infrequent) Ability to lift and carry objects up to 30 lbs. a distance of five (5) floors and to outlying buildings. (Frequent) Ability to maintain 20/40 vision, corrected. (Continuous) Ability to see and recognize objects close at hand. (Continuous) Ability to see and recognize objects at a distance. (Continuous) Ability to match or discriminate between colors. (Continuous) Ability to determine distance/relationship between objects; depth perception. (Continuous) Good peripheral vision capabilities. (Continuous) Ability to maintain hearing acuity, with correction. (Continuous) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to be qualified physically (by medical personnel) for respirator use, initially and annually. Ability to work alone in isolated areas, such as darkrooms. (Frequent) Additional New Requirements: Ability to obtain and maintain a valid drivers license. Computer literacy. Ability to work rotating shifts as required. Ability to work overtime as required. Ability to learn and use new processes, tools and equipment as required.

If you like working with energetic enthusiastic individuals, you will enjoy your career with us!

The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.

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